| 中文名稱 | 白介素13抗體 |
| 別 名 | ALRH; BHR 1; BHR1; IL 13; IL13; Interleukin 13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30; P600; IL13_MOUSE; Interleukin-13; IL-13; T-cell activation protein P600. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-13:45-56/131(mo) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Human IL13 was originally identified by differential screening of an anti CD28 activated human peripheral blood mononuclear cell cDNA library as an induction specific novel cytokine. It was also isolated from cDNA libraries of human T cell clones using the murine IL13 (P600) cDNA as a probe. Human IL13, a pleiotropic cytokine, is produced by activated Th0, Th1 like, Th2 like, and CD8 T cells. The gene for human IL13 maps to chromosome 5 and is closely linked to the genes for IL3, IL4, IL5, and GMCSF. IL13 inhibits proinflammatory cytokine production and stimulates antibody production. It induces proliferation in the human pre myeloid cell line TF1. IL13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression. IL13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity. Human and mouse interleukin 13 share approximately 58% amino acid sequence identity. Although human and mouse IL13 are equally active on human cells, human IL13 is much less active than mouse IL13 on mouse cells. Human IL13 and human IL4 also share approximately 30% sequence homology and have similar biological functions. Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Subcellular Location: Secreted. DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Similarity: Belongs to the IL-4/IL-13 family. SWISS: P20109 Gene ID: 16163 Database links: Entrez Gene: 3596 Human Entrez Gene: 16163 Mouse Entrez Gene: 116553 Rat Omim: 147683 Human SwissProt: P35225 Human SwissProt: P20109 Mouse SwissProt: P42203 Rat Unigene: 845 Human Unigene: 1284 Mouse Unigene: 9921 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長因子和激素（ Growth Factor and Hormones） IL-13是由Ｔ細胞、嗜堿粒細胞、漿細胞及樹突狀細胞產(chǎn)生的細胞因子。 IL-13誘導(dǎo)、維持一定IgE水平，增強巨噬細胞及樹突狀細胞活性，活化嗜酸粒細胞并防止其凋亡，廣泛參與過敏性及炎性疾病過程。 |
| 產(chǎn)品圖片 |  Sample:Lymph node (Mouse) Lysate at 40 ug Primary: Anti-IL-13 (bs-0560R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 12 kD Observed band size: 32 kD  Sample:Molt-4(Human) Cell Lysate at 30 ug Primary: Anti-IL-13 (bs-0560R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 12 kD Observed band size: 32 kD  Sample:Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-IL-13 (bs-0560R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 12 kD Observed band size: 27 kD  Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (bs-0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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