| 中文名稱 | 外周髓磷脂P0蛋白/P0蛋白抗體 |
| 別 名 | peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, Dog, (predicted: Human, Pig, Cow, Horse, Rabbit, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P0 protein:175-248/248 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the gene encoding Myelin protein-zero (MPZ) is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of ~28kDa, Myelin protein-zero is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein, myelin proteolipid protein and myelin-associated glycoprotein. Subunit: Homodimer and homotetramer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Found only in peripheral nervous system Schwann cells. Similarity: Belongs to the myelin P0 protein family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: P25189 Gene ID: 4359 Database links: Entrez Gene: 4359 Human Entrez Gene: 17528 Mouse Omim: 159440 Human SwissProt: P25189 Human SwissProt: P27573 Mouse Unigene: 591486 Human Unigene: 93883 Human Unigene: 9986 Mouse UniProtKB/Swiss-Prot: P25189.1
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 成熟的周圍神經(jīng)系統(tǒng)髓鞘主要的蛋白為P0蛋白，分子量28KDa，它具有單個(gè)跨膜區(qū)，是IgG超家族的成員之一。 |
| 產(chǎn)品圖片 |  Sample:Spinal cord (Rat) Lysate at 40 ug Primary: Anti- Myelin Protein Zero (bs-0337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 29 kD  Sample:Lane 1: Spinal cord (Mouse) Lysate at 40 ug Lane 2: Spinal cord (Rat) Lysate at 40 ug Lane 3: Adipose (Mouse) Lysate at 40 ug Lane 4: Adipose (Rat) Lysate at 40 ug Primary: Anti-Myelin Protein Zero (bs-0337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kD Observed band size: 28 kD  Sample:Bone (Mouse) Lysate at 40 ug Primary: Anti-Myelin Protein Zero (Bs- 0337R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 26 kD |
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