| 中文名稱 | P物質(zhì)抗體 |
| 別 名 | Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 1.4/13kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Substance P(RPKPQQFFGLM):58-68/129 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Subcellular Location: Secreted. Similarity: Belongs to the tachykinin family. SWISS: P20366 Gene ID: 6863 Database links: Entrez Gene: 6863 Human Entrez Gene: 21333 Mouse Entrez Gene: 24806 Rat Omim: 162320 Human SwissProt: P20366 Human SwissProt: P41539 Mouse SwissProt: P06767 Rat Unigene: 2563 Human UniProtKB/Swiss-Prot: P20366.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. P物質(zhì)（Substance P）是腦組織及消化道中發(fā)現(xiàn)的一種神經(jīng)遞質(zhì)肽。由130個氨基酸殘基組成，胃腸道中肌肉收縮的有力促進(jìn)劑，亦為強(qiáng)血管擴(kuò)張劑。 SP是一種腦腸肽，亦是最早發(fā)現(xiàn)的一種神經(jīng)肽，屬于速激肽家族成員，它廣泛分布于中樞及外周神經(jīng)系統(tǒng)，作為一種神經(jīng)遞質(zhì)或調(diào)質(zhì)參與疼痛、免疫、心血管等多種生理功能的調(diào)節(jié)。SP與其它的遞質(zhì)或調(diào)質(zhì)類似，能作用于多種類型的受體，速激肽家族有NK1、NK2、NK3三種受體，都能與SP結(jié)合，其中NK1與SP的結(jié)合能力最強(qiáng)而被稱為SP受體。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat adrenal gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with ( Substance P) Polyclonal Antibody, Unconjugated (0065R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Blank control: Mouse brain cells (blue). |
