| 中文名稱 | 內(nèi)脂素/內(nèi)臟脂肪素/前B細(xì)胞克隆增強(qiáng)因子1抗體 |
| 別 名 | pre-B-cell colony-enhancing factor 1; PBEF1 protein; AI480535; 1110035O14Rik; AI314458; DKFZP666B131; EC 2.4.2.12; MGC117256; NAmPRTase; NAMPT; Nicotinamide phosphoribosyltransferase; PBEF; PBEF1; Pre B cell colony enhancing factor 1; Pre B cell colony enhancing factor; Pre B cell enhancing factor; Visfatin; NAMPT_HUMAN. |
| 研究領(lǐng)域 | 心血管 神經(jīng)生物學(xué) 糖尿病 內(nèi)分泌病 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Chicken, Pig, Cow, Horse, Monkey, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PBEF:301-400/491 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]. Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Subunit: Homodimer. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. Similarity: Belongs to the NAPRTase family. SWISS: P43490 Gene ID: 10135 Database links: Entrez Gene: 10135 Human Entrez Gene: 59027 Mouse Entrez Gene: 297508 Rat Omim: 608764 Human SwissProt: P43490 Human SwissProt: Q99KQ4 Mouse SwissProt: Q80Z29 Rat Unigene: 489615 Human Unigene: 202727 Mouse Unigene: 203508 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 一種新的脂肪因子-visfatin是新近發(fā)現(xiàn)的主要由人和小鼠內(nèi)臟脂肪組織分泌的一種脂肪細(xì)胞因子,其結(jié)構(gòu)與pre-B細(xì)胞集落增強(qiáng)因子相似.它能夠發(fā)揮類似胰島素的作用,與Ⅱ型糖尿病相關(guān)聯(lián),降低血糖,促進(jìn)糖攝取,可結(jié)合并活化胰島素受體,激活胰島素信號(hào)通路.內(nèi)臟脂肪因子-Visfatin與肥胖密切相關(guān)并能夠促進(jìn)脂肪細(xì)胞的分化,還能促進(jìn)血管平滑肌細(xì)胞成熟. Visfatin的表達(dá)受炎癥反應(yīng)因子和多種激素的調(diào)節(jié).PBEF-1可能是聯(lián)系機(jī)體糖脂代謝的重要分子,它的發(fā)現(xiàn)可為揭示糖尿病與肥胖的發(fā)生發(fā)展機(jī)制提供新的研究思路,為代謝綜合征的治療提供新方案. |
| 產(chǎn)品圖片 |  Sample:Heart (Mouse) Lysate at 40 ug Primary: Anti-Visfatin (bs-0272R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD Sample: Lane1:Brain(Rat) Lysate at 30 ug Lane2:Liver (Rat) Lysate at 30 ug Primary: Anti-VISFATIN-1 (bs-0272R) at 1:200 dilution Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1: 3000 dilution Predicted band size : 55kD Observed band size : 54kD  Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti- Visfatin Polyclonal Antibody, Unconjugated(bs-0272R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining  Tissue/cell: Rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti- Visfatin Polyclonal Antibody, Unconjugated(bs-0272R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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