| 中文名稱 | 自噬相關蛋白13抗體 |
| 別 名 | ATG13 autophagy related 13 homolog; ATG13_HUMAN; Autophagy related protein 13; Autophagy-related protein 13; FLJ20698; KIAA0652. |
| 研究領域 | 腫瘤 新陳代謝 線粒體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Chicken, Dog, Cow, Horse, Rabbit, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 細胞定位 | 細胞漿 線粒體 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ATG13:51-150/517 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Subunit: Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus). Subcellular Location: Cytoplasm, cytosol.Preautophagosomal structure. Post-translational modifications: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria. Similarity: Belongs to the ATG13 metazoan family. SWISS: O75143 Gene ID: 9776 Database links: Entrez Gene: 507340 Cow Entrez Gene: 9776 Human Entrez Gene: 51897 Mouse Entrez Gene: 362164 Rat Entrez Gene: 393405 Zebrafish SwissProt: Q08DY8 Cow SwissProt: O75143 Human SwissProt: Q91YI1 Mouse SwissProt: Q7SYE0 Zebrafish Unigene: 127403 Human Unigene: 28492 Mouse Unigene: 98797 Rat Unigene: 82470 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品圖片 |  Sample: Brain (Rat) Lysate at 40 ugPrimary: Anti-ATG13 (bs-3864R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution Predicted band size: 57 kD Observed band size: 57 kD |
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