| 中文名稱 | 神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1/前蛋白轉(zhuǎn)化酶枯草溶菌素9抗體 |
| 別 名 | FH3; HCHOLA3; Hypercholesterolemia autosomal dominant 3; NARC 1; NARC-1; NARC1; Neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC 9; PC9; PCSK 9; PCSK9; PCSK9_HUMAN; Proprotein convertase 9; Proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; PSEC0052; Subtilisin/kexin like protease PC9; Subtilisin/kexin-like protease PC9. |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCSK9/NARC1:231-330/692 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. Function: The precursor protein but not the mature protein may form multimers. Subunit: The precursor protein but not the mature protein may form multimers. Subcellular Location: Secreted. Tissue Specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. Post-translational modifications: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. Similarity: Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain. SWISS: Q8NBP7 Gene ID: 255738 Database links: Entrez Gene: 255738 Human Entrez Gene: 100102 Mouse Entrez Gene: 298296 Rat Omim: 607786 Human SwissProt: Q8NBP7 Human SwissProt: Q80W65 Mouse SwissProt: P59996 Rat Unigene: 18844 Human Unigene: 133268 Mouse Unigene: 19195 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 前蛋白轉(zhuǎn)化酶枯草溶菌素9(PCSK9)是近年來(lái)新發(fā)現(xiàn)的一種與調(diào)節(jié)脂質(zhì)代謝密切相關(guān)的基因,編碼前蛋白轉(zhuǎn)化酶NARC-1。Narc-1/pcsk9可通過(guò)調(diào)節(jié)細(xì)胞表面的低密度脂蛋白受體(LDLR)水平,參與脂質(zhì)代謝,從而在動(dòng)脈粥樣硬化性疾病的發(fā)生、發(fā)展中發(fā)揮重要作用。 |
| 產(chǎn)品圖片 |  Sample:Lane 1: HepG2(Human) Cell Lysate at 30 ug Lane 2: SW480(Human) Cell Lysate at 30 ug Primary: Anti- NARC1/PCSK9 (bs-6060R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 72 kD Observed band size: 70 kD  Sample:Lane 1:A431(Human) Cell Lysate at 30 ug Lane 2:Uterus (Mouse) Lysate at 40 ug Primary: Anti- NARC1/PCSK9 (bs-6060R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 72 kD Observed band size: 70 kD  Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NARC1 PCSK9) Polyclonal Antibody, Unconjugated (bs-6060R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NARC1 PCSK9) Polyclonal Antibody, Unconjugated (bs-6060R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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