| 中文名稱 | 組蛋白甲基化KMT3B抗體（雄激素受體激活蛋白） |
| 別 名 | Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; ARA267; H3 K36 HMTase; H3-K36-HMTase; H4 K20 HMTase; H4-K20-HMTase; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; KMT3B; Lysine N-methyltransferase 3B; NR binding SET domain containing protein; NR-binding SET domain-containing protein; Nsd1; NSD1_HUMAN; Nuclear receptor binding SET domain containing protein 1; Nuclear receptor-binding SET domain-containing protein 1. |
| 研究領域 | 腫瘤 細胞生物 信號轉導 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產品應用 | ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 296kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KMT3B/NSD1/ARA267:2401-2600/2696 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Histone methyltransferase. Preferentially methylates'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro).Transcriptional intermediary factor capable of both negatively orpositively influencing transcription, depending on the cellularcontext. Subunit: Interacts with the ligand-binding domains of RARA andTHRA in the absence of ligand; in the presence of ligand theinteraction is severely disrupted but some binding still occurs.Interacts with the ligand-binding domains of RXRA and ESRRA only inthe presence of ligand. Interacts with ZNF496 (By similarity).Interacts with AR DNA- and ligand-binding domains. Subcellular Location: Nucleus. Chromosome (Probable). Tissue Specificity: Expressed in the fetal/adult brain, kidney,skeletal muscle, spleen, and the thymus, and faintly in the lung. DISEASE: Defects in NSD1 are the cause of Sotos syndrome type 1(SOTOS1) [MIM:117550]; also known as cerebral gigantism. It is adisorder characterized by excessively rapid growth, acromegalicfeatures, and a nonprogressive cerebral disorder with mentalretardation. High-arched palate and prominent jaw are noted inseveral patients. Most cases of Sotos syndrome are sporadic and mayrepresent new dominant mutation. Defects in NSD1 are the cause of Weaver syndrome type 1(WVS1) [MIM:277590]. A syndrome of accelerated growth and osseousmaturation, unusual craniofacial appearance, hoarse and low-pitchedcry, and hypertonia with camptodactyly. Distinguishing features ofWeaver syndrome include broad forehead and face, ocularhypertelorism, prominent wide philtrum, micrognathia, deephorizontal chin groove, and deep-set nails. In addition, carpalbone development is advanced over the rest of the hand. Defects in NSD1 are a cause of Beckwith-Wiedemannsyndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneousdisorder characterized by anterior abdominal wall defects includingexomphalos (omphalocele), pre- and postnatal overgrowth, andmacroglossia. Additional less frequent complications includespecific developmental defects and a predisposition to embryonaltumors. Note=A chromosomal aberration involving NSD1 is found inchildhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5)with NUP98. Note=A chromosomal aberration involving NSD1 is found inan adult form of myelodysplastic syndrome (MDS). Insertion of NUP98into NSD1 generates a NUP98-NSD1 fusion product. Similarity: Belongs to the histone-lysine methyltransferasefamily. Contains 1 AWS domain. Contains 4 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 2 PWWP domains. Contains 1 SET domain. SWISS: Q96L73 Gene ID: 64324 Database links: Entrez Gene: 64324 Human Omim: 606681 Human SwissProt: Q96L73 Human Unigene: 106861 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產品圖片 |  Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KMT3B) Polyclonal Antibody, Unconjugated (bs-8170R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KMT3B) Polyclonal Antibody, Unconjugated (bs-8170R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: Human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-KMT3B Polyclonal Antibody, Unconjugated(bs-8170R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining  Tissue/cell: Rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-KMT3B Polyclonal Antibody, Unconjugated(bs-8170R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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