| 中文名稱 | 代謝型谷氨酸受體-3抗體 |
| 別 名 | G protein coupled receptor family C group 1 member C; GLUR 3; GLUR3; GLUR3; Glutamate metabotropic receptor 3; Glutamate receptor metabotropic 3; GPRC1C; GRM 3; GRM3; GRM3_HUMAN; Metabotropic glutamate receptor 3; Metabotropic glutamate receptor 3 precursor; mGlu 3; MGlu3; MGlu3; MGLUR 3; MGLUR3. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=5μg/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 96kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Metabotropic Glutamate Receptor 3:365-460/879 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Subunit: nteracts with GRASP Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: Q14832 Gene ID: 2913 Database links: Entrez Gene: 2913 Human Entrez Gene: 108069 Mouse Entrez Gene: 24416 Rat Omim: 601115 Human SwissProt: Q14832 Human SwissProt: Q9QYS2 Mouse SwissProt: P31422 Rat Unigene: 590575 Human Unigene: 318966 Mouse Unigene: 41715 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品圖片 |  Sample:Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 96 kD Observed band size: 116 kD  Sample:Cerebral cortex (Mouse) Lysate at 40 ug Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 96 kD Observed band size: 116 kD  Sample:Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-MGLUR3 (bs-12012R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 96 kD Observed band size: 116 kD  Blank control: Mouse Liver Cells(fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice).Primary Antibody: Rabbit Anti- MGLUR3/PE Conjugated antibody (bs-12012R-PE), Dilution: 5μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/PE(orange) ,used under the same conditions. |
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