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中文名稱

生長分化因子15/巨嗜細(xì)胞抑制因子1抗體

別名

GDF 15; GDF-15; GDF15_HUMAN; Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; Mic-1; MIC1; NAG 1; NAG-1; NAG1; NRG 1; NRG-1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; Placental TGF-beta; Prostate differentiation factor; PTGF beta; PTGFB.

研究領(lǐng)域	腫瘤細(xì)胞生物免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡生長因子和激素轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源	Rabbit
克隆類型	Polyclonal
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	12.5/34kDa
細(xì)胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GDF-15:221-308/308
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Similarity: Belongs to the TGF-beta family. SWISS: Q99988 Gene ID: 9518 Database links: Entrez Gene: 9518 Human Entrez Gene: 23886 Mouse Entrez Gene: 29455 Rat Omim: 605312 Human SwissProt: Q99988 Human SwissProt: Q9Z0J7 Mouse SwissProt: Q9Z0J6 Rat Unigene: 616962 Human Unigene: 31325 Mouse Unigene: 44228 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長分化因子15（GDF15）是骨形態(tài)發(fā)生蛋白（BMP）和轉(zhuǎn)化生長因子-β超家族成員。GDF-15又叫巨噬細(xì)胞抑制因子（macrophage inhibiting cytokine，MIC）-1、胎盤轉(zhuǎn)化生長因子（placental transformation growth factor，PTGF）-β、前列腺衍生因子（prostate derived factor，PDF）和胎盤骨形態(tài)發(fā)生蛋白（placental bone morphogeneticprotein，PLAB）。有學(xué)者認(rèn)為：GDF-15在腫瘤發(fā)展的不同階段發(fā)揮著不同的生物學(xué)作用；隨著腫瘤的發(fā)生發(fā)展，GDF-15可能表達不同形式的蛋白，在腫瘤發(fā)生的早期階段可能發(fā)揮抑瘤作用，而在腫瘤發(fā)展的后期階段發(fā)揮促瘤作用。
產(chǎn)品圖片	Sample: Lane 1: Urinary bladder (Mouse) Lysate at 40 ug Lane 2: Large intestine (Mouse) Lysate at 40 ug Lane 3: Urinary bladder (Rat) Lysate at 40 ug Lane 4: Large intestine (Rat) Lysate at 40 ug Lane 5: HT1080 (Human) cell Lysate at 40 ug Lane 6: HepG2 (Human) cell Lysate at 40 ug Lane 7: K562 (Human) cell Lysate at 40 ug Lane 8: A549 (Human) cell Lysate at 40 ug Primary: Anti-GDF15 (bs-3818R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD Sample: K562 Cell Lysate at 30 ug A431 Cell Lysate at 30 ug Primary: Anti-GDF15 (bs-3818R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size:34 kD Observed band size:30 kDParaformaldehyde-fixed, paraffin embedded (Mouse placenta); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GDF15) Polyclonal Antibody, Unconjugated (bs-3818R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.