| 中文名稱 | 膽囊收縮素8抗體 |
| 別 名 | CCK 8; CCK; CCK8; CCK-8; Cholecystokinin 8; Cholecystokinin;Cholecystokinin preproprotein; Cholecystokinin8; Cholecystokinins precursor; MGC117187; Procholecystokinin precursor; CCKN_HUMAN. |
| 研究領(lǐng)域 | 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500 IHC-F=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12.6kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCK8:96-103/115 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]. Function: Cholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo. Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain. Subcellular Location: Secreted. Tissue Specificity: The shortest form (CCK8) is predominantly found in the brain, whereas the larger ones are found in the intestine. Similarity: Belongs to the gastrin/cholecystokinin family. SWISS: P06307 Gene ID: 885 Database links: Entrez Gene: 885 Human Entrez Gene: 12424 Mouse Entrez Gene: 25298 Rat Omim: 118440 Human SwissProt: P06307 Human SwissProt: P09240 Mouse SwissProt: P01355 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 八肽膽囊收縮肽抗體CCK8在近期的研究中受到很大關(guān)注，學(xué)者認(rèn)為：CCK8是一種神經(jīng)內(nèi)分泌肽，也是一種激素，主要是參與神經(jīng)元的信號轉(zhuǎn)導(dǎo)，尤其在中樞神經(jīng)系統(tǒng)中的信號傳遞機(jī)制中起到很重要的作用。 膽囊收縮素八肽是國際上公認(rèn)的有生物活性的多肽片斷。 膽囊收縮素：為多種分子形式的多肽，人工合成的八肽膽囊收縮素（CCK8）具有全部天然活性： 1.在胃腸道和大腦廣泛存在。對消化系統(tǒng)的作用包括收縮膽囊、促進(jìn)胰酶和碳酸氫鹽的分泌。抑制食管下括約肌、oddi氏括約肌收縮及近端十二指腸蠕動，增強(qiáng)遠(yuǎn)端十二指腸和空腸的蠕動。 2.在中樞神經(jīng)系統(tǒng)可發(fā)揮神經(jīng)遞質(zhì)作用，對大腦一些細(xì)胞產(chǎn)生興奮影響。作用于下丘腦飲食中樞導(dǎo)致厭食，通過刺激腦內(nèi)啡肽的釋放產(chǎn)生鎮(zhèn)痛作用。 3.CCK8 同源性較高，如：CCK12、CCK58、CCK39、CCK33等 |
| 產(chǎn)品圖片 |  Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCK8) Polyclonal Antibody, Unconjugated (bs-0764R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCK8) Polyclonal Antibody, Unconjugated (bs-0764R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCK8) Polyclonal Antibody, Unconjugated (bs-0764R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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