英文名稱 ADAM17 (9E7) 
中文名稱 ADAM17重組兔單克隆抗體 
別    名 A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17_HUMAN.   
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子   
抗體來源 Rabbit 
克隆類型 Monoclonal 
克 隆 號(hào) 9E7 
交叉反應(yīng) Human, Mouse,  (predicted: Rat, ) 
產(chǎn)品應(yīng)用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 ICC=1:20-200 IF=1:20-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. 
分 子 量 93kDa 
細(xì)胞定位 細(xì)胞膜  
性    狀 Liquid 
濃    度 1mg/ml 
免 疫 原 Recombinant human ADAM17 protein:700-824/824  
亞    型 IgG 
純化方法 affinity purified by Protein A 
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 
PubMed PubMed 
產(chǎn)品介紹 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
 
Subunit:
Interacts with MAD2L1, MAPK14 and MUC1.
 
Subcellular Location:
Membrane.
 
Tissue Specificity:
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
 
產(chǎn)品圖片
Sample:
Pancreas (Mouse) Lysate at 40 ug
Primary: Anti-ADAM17 (9E7) (bsm-52009R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 93 kD
Observed band size: 93 kD
Sample:
Spleen (Mouse) Lysate at 40 ug
Jurkat(Human) Cell Lysate at 30 ug
SW480(Human) Cell Lysate at 30 ug
Primary: Anti- ADAM17 (9E7) (bsm-52009R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 93 kD
Observed band size: 100 kD