中文名稱(chēng) 神經(jīng)生長(zhǎng)因子β重組兔單克隆抗體
別 名 Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN.
研究領(lǐng)域 發(fā)育生物學(xué) 神經(jīng)生物學(xué) 細(xì)胞因子
抗體來(lái)源 Rabbit
克隆類(lèi)型 Monoclonal
克 隆 號(hào) 11G1
交叉反應(yīng) Mouse, Rat, (predicted: Human, Zebrafish, )
產(chǎn)品應(yīng)用 WB=1:1000-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13/32kDa
細(xì)胞定位 分泌型蛋白
性 狀 Liquid
濃 度 1mg/ml
免 疫 原 Recombinant human NGF:
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
產(chǎn)品介紹 This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
Subunit:
Homodimer.
Subcellular Location:
Secreted.
DISEASE:
Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and
| 產(chǎn)品圖片 |  Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Lane 3: Heart (Mouse) Lysate at 40 ug Lane 4: Heart (Rat) Lysate at 40 ug Lane 5:Spleen (Rat) Lysate at 40 ug Lane 6: Placenta (Mouse) Lysate at 40 ug Primary: Anti-NGF (bsm-52362R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 34 kD |
