| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Livin: 101-200/298 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Livin is a novel member of the IAP protein family and contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. The two isoforms of Livin appear to have different functions and tissue distributions. Function: Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Subcellular Location: Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm. Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. Similarity: Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger. SWISS: Q96CA5 Gene ID: 79444 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Livin—屬于凋亡蛋白抑制因子家族（inhibitor of apoptosis proteins，IAP） Livin是凋亡抑制蛋白家族的新成員，主要通過抑制Caspases蛋白發(fā)揮抑制細(xì)胞凋亡的作用,主要在胎盤組織中表達，同時在一些腫瘤組織中呈高表達，尤其是在黑色素瘤細(xì)胞系表達水平最高。 經(jīng)研究表明，Livin與腫瘤的發(fā)生、發(fā)展關(guān)系密切,是一個有潛在價值的腫瘤標(biāo)志物，此外，反義Livin以及Livin活性抑制物的研究有望成為腫瘤治療的新靶點。 |
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