| 產(chǎn)品編號(hào) | bs-2687R |
| 英文名稱(chēng) | FOXM1 |
| 中文名稱(chēng) | 叉頭蛋白M1抗體 |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Dog, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 84kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOXM1: 301-400/801 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The Forkhead Box (Fox) proteins are an extensive family of transcription factors that share homology in the winged helix DNA-binding domain and the members of which play essential roles in a diverse range of developmental processes as well as cellular proliferation, differentiation, and longevity. The Fox factors are especially important in the establishment of the body axis and the development of tissues from all three germ layers. FOXM1 is also overexpressed in many human cancers and has a role in tumorigenesis. Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Subcellular Location: Nucleus. Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis. Post-translational modifications: Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: Q08050 Gene ID: 2305 Database links:
FOXM1(Forkhead box M1)是Forkhead轉(zhuǎn)錄因子家族中的成員，在很多腫瘤組織中都有不同的表達(dá)。 |
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