| 產(chǎn)品編號 | Ys-2470R |
| 英文名稱 | CD244 |
| 中文名稱 | CD244抗體 |
| 研究領(lǐng)域 | 細胞生物 免疫學 干細胞 細胞粘附分子 細胞表面分子 自然殺傷細胞 淋巴細胞 t-淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 42kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD244: 151-250/370 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] Function: Modulate other receptor-ligand interactions to enhance leukocyte activation. Subunit: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. Similarity: Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: Q9BZW8 Gene ID: 51744 |
| 產(chǎn)品圖片 |  Sample: Lane 1: Rat Thymus tissue lysates Lane 2: Rat Lymph node tissue lysates Lane 3: Human Serum Primary: Anti-CD244 (Ys-2470R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size:42 kD Observed band size:70 kD  Cell: A549 (2% Paraformaldehyde fixed for 10 minutes). Concentration: primary antibody, 1:100;Secondary antibody,1: 50. Incubation: primary antibody ,1 hour;Secondary antibody,40 minutes; at Room temperature. Host/Blank: A549. Flow cytometric analysis of Rabbit Anti-CD244 antibody (bs-2470R)(green) compared with control in the absence of primary antibody (blue) followed by A549. Secondary antibody: Goat Anti-rabbit IgG/FITC antibody (Ys-0295G-FITC) |
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