| 產品編號 | Ys-0315R |
| 英文名稱 | FGL2 |
| 中文名稱 | 凝血酶原酶/纖維蛋白原2抗體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Rat, |
| 產品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 49kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Rat FGL2: 75-150/422 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 | FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1. Function: May play a role in physiologic lymphocyte functions at mucosal sites Subunit: Homotetramer; disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: Constitutively expressed in cytotoxic T-cells. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: N/A Gene ID: 84586 fgL-2蛋白是新近發(fā)現的一種凝血因子，它通過直接激活凝血酶原啟動凝血過程。一 系列實驗證明，該蛋白在肝細胞壞死中起到重要作用。對乙肝患者肝組織免疫組織化學染色hfg12在重型乙型肝炎患者高表達。 凝血酶原酶(簡稱fgl2)蛋白屬于纖維蛋白原家族的一員,由活化的巨噬細胞表達,具有凝血酶原酶的活力,能催化凝血酶原轉化為凝血酶,啟動凝血過程. |
| 產品圖片 |  Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-fg-12 Polyclonal Antibody, Unconjugated(bs-0315R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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