| 產(chǎn)品編號(hào) | Ys-1896R |
| 英文名稱(chēng) | SOCS2 |
| 中文名稱(chēng) | 細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白2抗體 |
| 別 名 | suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; SOCS 2; Cish2; SSI-2; STATI2; SOCS2_HUMAN. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Socs2: 1-100/198 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Subunit: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. Tissue Specificity: High expression in heart, placenta, lung, kidney and prostate. Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. SWISS: O14508 Gene ID: 8835 細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一類(lèi)由細(xì)胞產(chǎn)生并反饋性阻斷細(xì)胞因子信號(hào)轉(zhuǎn)導(dǎo)過(guò)程的負(fù)性調(diào)節(jié)因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多種細(xì)胞因子的信號(hào)轉(zhuǎn)導(dǎo)，對(duì)體內(nèi)多種免疫反應(yīng)的激活起調(diào)控作用。SOCS2異常表達(dá)與多種疾病的發(fā)病相關(guān)，在急慢性白血病、類(lèi)風(fēng)濕性關(guān)節(jié)炎、肝硬化和肝癌的發(fā)病中起重要作用；對(duì)信號(hào)轉(zhuǎn)導(dǎo)，特別是JAKSTAT通路的負(fù)調(diào)控作用已被肯定。 |
| 產(chǎn)品圖片 |  Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (SOCS2) Polyclonal Antibody, Unconjugated (bs-1896R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining. |
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