產(chǎn)品編號 Ys-2420R
英文名稱 NCR2
中文名稱 細(xì)胞毒性受體NK-p44抗體
別 名 Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Lymphocyte antigen 95 (activating NK receptor; NK p44); Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; NK cell activating receptor; NK p44; NKp44; NCTR2_HUMAN; dJ149M18.1; Lymphocyte antigen 95 (activating NK receptor; NK p44).
研究領(lǐng)域 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體 自然殺傷細(xì)胞 t-淋巴細(xì)胞
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,
產(chǎn)品應(yīng)用 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 28kDa
細(xì)胞定位 細(xì)胞膜
性 狀 Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD336: 201-276/276
亞 型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1
Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subunit:
Interacts with TYROBP/DAP12.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contain
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