| 產(chǎn)品編號 | Ys-1573R |
| 英文名稱 | BBC3/PUMA |
| 中文名稱 | p53正向細胞凋亡調(diào)控因子抗體 |
| 別 名 | PUMA; bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1; BBC3_RAT. |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 21kDa |
| 細胞定位 | 細胞漿 線粒體 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BBC3: 131-180/193 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] Function: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Essential for ER stress-induced cell death. Subunit: Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1. Subcellular Location: Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. Similarity: Belongs to the Bcl-2 family. SWISS: Q96PG8 Gene ID: 27113 PUMA在由p53誘導(dǎo)而經(jīng)歷細胞凋亡的細胞中被p53活化。在線粒體，PUMA 誘導(dǎo)細胞色素C的釋放和激活對細胞凋亡的快速誘導(dǎo)。PUMA 與Bcl2、Bcl-XL、類Bcl2-1蛋白相互作用，促使線粒體易位和BAX的多聚化。PUMA在通過依賴細胞色素C/APAF1 途徑介導(dǎo)p53誘導(dǎo)的細胞死亡中也發(fā)揮作用。 |
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