| 產(chǎn)品編號 | Ys-1844R |
| 英文名稱 | LRIG1 |
| 中文名稱 | LRIG1抗體 |
| 別 名 | leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1; Leucine rich repeat protein; leucine rich repeats and immunoglobulin like domains 1; LIG 1; LIG-1; LRIG1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 120kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRIG1: 1001-1093/1093 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | LRIG1 protein is coded by a gene on a chromosome band 3p14.3, a region known to be deleted in various human cancers. It is considered to be a tumour suppressor gene. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues. Its 143kDa form may be cleaved into 111kDa and 32kDa fragments. The protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor. Subunit: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q96JA1 Gene ID: 26018 LRIG1屬于LRIGs基因家族。LRIGs是新發(fā)現(xiàn)的一類基因，在哺乳動(dòng)物體內(nèi)廣泛存在，目前發(fā)現(xiàn)該家族至少包括三個(gè)成員：LRIG1、LRIG2和LRIG3，是一類結(jié)構(gòu)相似的跨膜糖蛋白，該蛋白人、鼠的同源性較高。 目前在腫瘤方面的研究較多，有研究認(rèn)為：LRIG1是通過下調(diào)EGFR的表達(dá)來抑制其下游重要信號傳導(dǎo)通路的激活而發(fā)揮抑癌作用，LRIG1在抑制腫瘤轉(zhuǎn)移中具有重要作用。< |
| 產(chǎn)品圖片 |  Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-LRIG1 Polyclonal Antibody, Unconjugated(bs-1844R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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