Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant mature human TPP1 expressed in E. coli.
- Formulation
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For immunohistochemistry, a concentration range of 1.0 - 5.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone does not recognize rodent (mouse or rat) TPP1.
- Application References
(PubMed link indicates BioLegend citation) -
- Wujek P, et al. 2004. J. Biol. Chem. 279:12827-39.
- RRID
- AB_2783421 (BioLegend Cat. No. 852203) AB_2783422 (BioLegend Cat. No. 852204)
Antigen Details
- Structure
- Human TPP1 is a 563 amino acid protein with a molecular mass of 61 kD. An isoform of 34.5 kD and 320 amino acids (244-563) is generated by alternative splicing.
- Distribution
-
Tissue sources: Ubiquitously expressed. Highest levels in heart, placenta, bone marrow, lung, pineal, and lymphocytes.
Cellular distribution: Lysosome and extracellular. - Function
- TPP1 cleaves tripeptides from the N-termini of substrates in lysosomes and has endopeptidase activity.
- Interaction
- CLN5.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Proteases, Enzymes and Regulators
- Antigen References
-
- Getty AL, Pearce DA. 2011. Cell Mol. Life Sci. 68:453-74.
- Cárcel-Trullols J, et al. 2015. Biochim. Biophys. Acta. 2242-55.
- Kytt?l? A, et al. 2006. Biochim Biophys Acta. 920-33.
- Gene ID
- 1200 View all products for this Gene ID
- UniProt
- View information about TPP1 on UniProt.org
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