Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial c-REL recombinant protein (453-587 a.a.)
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- Affinity purified
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ChIP - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. For ChIP applications, the suggested dilution is 1:50-1:100 by volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2562203 (BioLegend Cat. No. 655802)
Antigen Details
- Structure
- 619 amino acids, predicted molecular weight of 69 kD, contains a RHD (Rel-like) domain responsible for dimerization and DNA binding, contains two C-terminal transactivation domains
- Distribution
-
Cytoplasm, translocated to the nucleus upon activation
- Function
- Transcription factor belonging to the NF-κB family, regulates various biological processes including tumorgenesis, inflamation, immune response, cell proliferation, and differentiation
- Interaction
- Forms homo or heterodimer with other NF-κB family members; interacts with NKIRAS1, NFKBIB, NFKBIE, IRF-8, and Foxp3
- Cell Type
- B cells, Tregs
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Signal Transduction, Transcription Factors
- Molecular Family
- Nuclear Markers, TCRs
- Antigen References
-
1. Bash J, et al. 1997. Mol. Cell Biol. 17:6526.
2. Chen G, et al. 2010. J. Immunol. 185:2350.
3. Gilmore TD, et al. 2011. Genes Cancer 2:695.
4. Ferch U, et al. 2007. Nat. Immunol. 8:984.
5. Sanjabi S, et al. 2005. Genes Dev. 19:2138.
6. Yamazaki T, et al. 2003. Nat. Immunol. 4:780. - Gene ID
- 5966 View all products for this Gene ID
- UniProt
- View information about c-REL on UniProt.org
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