Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length recombinant protein expressed in E. Coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Dazzle? 594 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* PE/Dazzle? 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
- AB_2894494 (BioLegend Cat. No. 366715) AB_2894494 (BioLegend Cat. No. 366716)
Antigen Details
- Structure
- Cytokine.
- Distribution
-
Thymic lymphomas, T cells, activated T cells, macrophages, mast cells, and Th17.
- Function
- Enhances the production of acute phase proteins in HepG2 cells and promotes Th17 cells to trasmigrate through the blood-brain barrier in multiple sclerosis.
- Interaction
- IL-22 receptor.
- Ligand/Receptor
- IL-22R1 and IL-10R2 receptor chains.
- Cell Type
- Embryonic Stem Cells, Macrophages, Mast cells, T cells, Th17
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Nagalakshmi ML, et al. 2004. Int. Immunopharmacol. 5:679.
2. Kebir H,, et al. 2007. Nat. Med. 13:1173.
3. Gu Y, et al. 2008. Eur. J. Immunol. 38:1807.
4. Pene Y, et al. 2008. J. Immunol. 180:7423.
5. Dumotier L, et al. 2000. J. Immune 164:1814.
6. Xie MH, et al. 2000. J. Biol. Chem. 40:31335.
7. Kotenko SV, et al. 2001. J. Immunol. 166:7096.
8. Chung Y, et al. 2006. Cell Res. 11:902.
9. Trifari S, et al. 2009. Nat. Immunol. 10:864. - Gene ID
- 50616 View all products for this Gene ID
- UniProt
- View information about IL-22 on UniProt.org
