Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human Oct4 recombinant protein (1-141aa).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ChIP - Quality tested
WB, ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by ChIP. For ChIP, the suggested use of this reagent is 1:50 to 1:100?by volume. For Western blotting, the suggested working dilution(s): Use 0.5 ?g/ml antibody dilution buffer for each mini-gel. For immunocytochemistry, a concentration of 2.5 ?g/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2716040 (BioLegend Cat. No. 653713) AB_2716041 (BioLegend Cat. No. 653714)
Antigen Details
- Structure
- Belongs to the POU transcription factor family, predicted molecular weight of 39 kD
- Distribution
-
Nuclear protein, expressed in undifferentiated embryonal carcinoma (EC) cells, embryonic stem (ES) cells and embryonic germ (EG) cells
- Function
- Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Oct4 is a prime candidate for an early developmental control gene. It also is an important marker of the undifferentiated state and central regulator of pluripotency in ES cells.
- Interaction
- SOX2, SOX8, SOX10, androgen receptor, and ETS2
- Biology Area
- Cell Biology, Immunology, Stem Cells, Transcription Factors
- Antigen References
-
1. Niwa H, et al. 2000. Nature Genet. 24:372.
2. Wernig M, et al. 2007. Nature 448:318.
3. Pesce M, et al. 2001. Stem Cells 19:271. - Gene ID
- 5460 View all products for this Gene ID
- UniProt
- View information about Oct4 on UniProt.org
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