Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human NLRP12 recombinant protein (93-1061 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565493 (BioLegend Cat. No. 675202)
Antigen Details
- Structure
- 1061 amino acids with a predicted molecular weight of 120 kD. Contains a DAPIN domain, a NACHT-associated domain, and eight leucine-rich repeats (LRR).
- Distribution
- Cytoplasm.
- Function
- NLRP12 negatively regulatres inflammation through attenuating both canonical and non-canonical NF-κB signaling.
- Interaction
- Interacts with ASC and FAF1 through its DAPIN domain.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Allen IC. 2014. Front Immunol. 5:169.
2. Zaki MH, et al. 2014. Proc. Natl. Acad. Sci. USA 111:385.
3. Chen GY. 2014. Eur. J. Immunol. 44:321.
4. Vladimer GI. 2013. Curr. Opin. Microbiol. 16:23.
5. Allen IC, et al. 2012. Immunity 36:742.
6. Vladimer GI, et al. 2012. Immunity 37:96. - Gene ID
- 91662 View all products for this Gene ID
- UniProt
- View information about NLRP12 on UniProt.org
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