Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial RAG2 recombinant protein (70-516 aa).
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- Preparation
- Affinity purified.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5-2.5 ?g/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application
- RRID
- AB_2561891 (BioLegend Cat. No. 654902)
Antigen Details
- Structure
- 527 amino acids, predicted molecular weight of 59 kD. Containing a core RAG domain with DNA cleavage activity and an atypical PHD domain responsible for binding of trimethylated histone H3 (H3K4me3) and phospholipids.
- Distribution
- Nucleus.
- Function
- RAG2 protein acts as a core subunit of the RAG complex, which is responsible for V(D)J recombination of T-cell receptors and immunoglobulins.
- Interaction
- Interacts with RAG1, HMG1, and HMG2 in V(D)J recombination protein-DNA complexes.
- Cell Type
- B cells, Tregs
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Neuroscience
- Molecular Family
- TCRs
- Antigen References
-
1. Fugmann SD, et al. 2000. Annu. Rev. Immunol. 18:495.
2. Oettinger MA. 1992. Trends Genet. 8:413.
3. Hillion S, et al. 2009. Autoimmun. Rev. 8:599.
4. Deriano L, et al. 2011. Nature 471:119.
5. van Til NP, et al. 2012. Mol Ther. 20:1968.
6. Jones JM and Simkus C, et al. 2009. Arch. Immunol. Ther. Exp. 57:105. - Gene ID
- 5897 View all products for this Gene ID
- UniProt
- View information about RAG2 on UniProt.org
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