Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human HSP90β recombinant protein (209-488 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.125 - 1.0 ?g per ml.?For immunoprecipitation, the suggested use of this reagent is 10-30 μg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2565512 (BioLegend Cat. No. 675402)
Antigen Details
- Structure
- Hsp90α: 732 amino acids with a predicted molecular weight of approximately 85 kD. Hsp90β: 724 amino acids with a predicted molecular weight of approximately 83 kD.
- Distribution
-
Nucleus and cytoplasm.
- Function
- Hsp90 is one of the most abundant molecular chaperones. It modulates the stability and transport of critical factors that include regulatory, metabolic, organizational, and signaling proteins.
- Interaction
- NR3C1, FKBP4, FKBP5, PPID, PPP5C, STIP1, AHSA1, FNIP1, HSF1, SMYD3, TOM34, TERT, PTGES3, CHORDC1, DNAJC7, STUB1, UBE2N, PPP5C, PPP5C, p53/TP53, and CDK6.
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Signal Transduction
- Molecular Family
- Heat Shock Proteins
- Antigen References
-
1. Barrott JJ, et al. 2013. FEBS J. 280:1381.
2. Gorska M, et al. 2012. Front. Biosci. (Landmark Ed) 17:2269.
3. Barginear MF, et al. 2008. Curr. Cancer Drug Targets 8:522.
4. Arya R, et al. 2007. J. Biosci. 32:595.
5. Neckers L, et al. 2003. Curr. Opin. Oncol. 15:419.
6. Nemoto T, et al. 1997. J. Biol. Chem. 272:26179. - Gene ID
- 3320 View all products for this Gene ID 3326 View all products for this Gene ID
- UniProt
- View information about Hsp90alpha/beta on UniProt.org
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