Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- SW-1573 cells selected by resistance on doxorubicin.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ICC, IHC-F, IP - Reported in the literature, not verified in house - Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Arceci RJ, et al. 1993. Cancer Res. 53:310.
- Arceci RJ, et al. 1992. Blood 80:1528-36.
- Schinkel AH, et al. 1993. Int. J. Cancer 55:478.
- Huet S, et al. 1998. Cytometry 34(6):248-56.
- Müller MR, et al. 2000. Int. J. Clin. Pharmacol. Ther. 38:180-6.
- Den Boer ML, et al. 1997. Leukemia 11:1078-85.
- Product Citations
-
- RRID
- AB_2571901 (BioLegend Cat. No. 919403)
Antigen Details
- Structure
- Member of ABC transporter family with an approximate molecular weight of 170 kD. Consists of two homologous halves, each comprising two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs).
- Distribution
-
Hematopoietic stem cells, T and B cells, natural killer (NK) cells, and many multidrug resistant neoplastic cells.
- Function
- Transports various molecules across cellular membranes and is involved in multidrug resistance.
- Cell Type
- B cells, Hematopoietic stem and progenitors, NK cells, T cells
- Biology Area
- Cancer Biomarkers, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Dulucq S, et al. 2008. Blood 112:2024.
- Gottesman MM, et al. 2009. Nat. Biotechnol. 27:546.
- Andreadis C, et al. 2007. Blood 109:3409.
- Gene ID
- 5243 View all products for this Gene ID
- UniProt
- View information about CD243 on UniProt.org
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