Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human TAL1 recombinant protein (1-263 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. For immunocytochemistry, a concentration range of 1.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2566441 (BioLegend Cat. No. 681001) AB_2566442 (BioLegend Cat. No. 681002)
Antigen Details
- Structure
- 331 amino acids with a predicted molecular weight of 34.3 kD. Contains a helix-loop-helix (bHLH) domain that is responsible for DNA binding and protein to protein interaction.
- Distribution
-
Nucleus.
- Function
- TAL1 is a bHLH transcription factor that regulates hematopoietic and vascular development. Ectopic expression of TAL1 is linked to T-cell acute lymhoblastic leukemia (T-ALL).
- Interaction
- Forms heterodimers with TCF3. Interacts with ETS1, LMO2, and DRG1.
- Biology Area
- Cell Biology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Wu W, et al. 2014. Genome Res. 24:1945.
2. Kolodziej S, et al. 2014. Nat. Commun. 5:3995.
3. Palii CG, et al. 2014. Cell Stem Cell 14:644.
4. Yun WJ, et al. 2014. Nucleic Acids Res. 42:4283.
5. Zhou Y, et al. 2013. Blood 26:4199.
6. Sanda T, et al. 2012. Cancer Cell 22:209. - Gene ID
- 6886 View all products for this Gene ID
- UniProt
- View information about TAL1 on UniProt.org
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