Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial recombinant protein (isoform 1, 101-308 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
RORa has two isoforms, 53 kD and 59 kD, and this antibody recognizes both isoforms.
This antibody does not recognize human.
- RRID
- AB_2566748 (BioLegend Cat. No. 683102)
Antigen Details
- Structure
- 523 amino acids with a predicted molecular weight of 59 kD. RORs contain four major functional domains: an amino-terminal domain, DNA domain (DBD), a hinge domain, and a ligand-binding domain (LBD).
- Distribution
-
Nucleus.
- Function
- RORα can bind as a monomer or homodimer to hormone response elements upstream of several genes to enhance the expression of those genes.
- Interaction
- RORα interacts with p300, beta-catenin, HIF1A, NCOA2, CEBPB, FOXP3, and NRIP1.
- Biology Area
- Cell Biology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Giguere V, et al. 1994. Genes Dev. 8:538.
2. Atkins GB, et al. 1999. Mol. Endocrinol. 13:1550.
3. Dzhagalov I, et al. 2004. 173:2952.
4. Yang XO, et al. 2008. Immunity 28:29.
5. Lee JM, et al. 2012. Mol. Cell 48:572.
6. Solt LA, et al. 2012. Trends Endocrinol Metab. 23:619. - Gene ID
- 6095 View all products for this Gene ID
- UniProt
- View information about RORalpha on UniProt.org
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