Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human mTOR recombinant protein (1186-1385 aa) expressed in E. coli.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2563155 (BioLegend Cat. No. 659201) AB_2563156 (BioLegend Cat. No. 659202)
Antigen Details
- Structure
- 2549 amino acids encode a protein with predicted MW of 289 kD.
- Distribution
-
Nucleus, Cytoplasm
- Function
- The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.
- Interaction
- Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40, and DEPTOR; also part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1, and DEPTOR.
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Signal Transduction
- Antigen References
-
1. Brown EJ, et al. 1994. Nature. 369:756.
2. Dennis P, et al. 2001. Science. 294:1102.
3. Fingar D, et al. 2002. Genes Dev. 16:1472.
4. Nojima H, et al. 2003. J. Biol. Chem. 278:15461. - Gene ID
- 2475 View all products for this Gene ID
- UniProt
- View information about mTOR on UniProt.org
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