Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human NLRC4 recombinant protein (1-88 aa)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2563347 (BioLegend Cat. No. 659702)
Antigen Details
- Structure
- 1024 amino acids, predicted molecular weight of 116 kD. Contains a CARD domain, a NACHT domain, and 14 leucine-rich repeats.
- Distribution
-
Cytoplasm.
- Function
- NLRC4 is involved in the assembly of the inflammasome complex, activation of pro-caspase-1, and induction of matured proinflammatory cytokines during bacterial infections.
- Interaction
- Foms homo-oligomer in NLRC4 inflammasome. Interacts with Caspase-1, ASC, NOD2, NALP1, and BCL10.
- Cell Type
- Dendritic cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Cai S, et al. 2012. J. Immunol. 188:5623.
2. Franchi L, et al. 2012. Nat. Immunol. 13:449.
3. Carvalho FA, et al. 2012. Mucosal Immunol. 5:288.
4. Tomalka J, et al. 2011. PLoS Pathog. 7:e1002379.
5. Pereira MS, et al. 2011. J. Immunol. 187:6447.
6. Sauer JD, et al. 2011. Proc. Natl. Acad. Sci. USA. 108:12419. - Gene ID
- 58484 View all products for this Gene ID
- UniProt
- View information about NLRC4 on UniProt.org
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