Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Peptide (HQRIH(pT)GEKPYKC) conjugated to KLH.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 ?g/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2566052 (BioLegend Cat. No. 678902)
Antigen Details
- Structure
- Conserved linker region (HTGEKP) of C2H2 zinc finger proteins.
- Distribution
-
Mitotic cells.
- Function
- The linker region (HTGEKP) of C2H2 zinc finger proteins facilitate stable DNA binding and is highly conserved among these zinc finger proteins. During mitosis, C2H2 zinc finger proteins are phosphorylated on the threonine residue of the linker peptide, which result in the inactivation of their DNA binding activity.
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Transcription Factors
- Molecular Family
- Phospho-Proteins
- Antigen References
-
1. Dovat S, et al. 2002. Genes Dev. 16:2985.
2. Rizkallah R, et al. 2011. Cell cycle 10:3327.
3. Rizkallah R, et al. 2015. Oncotarget 6:1446. - Gene ID
- NA
- UniProt
- View information about C2H2 zinc finger proteins on UniProt.org
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