Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial NLRP2 recombinant protein (60-192 aa) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- Upon receipt, store undiluted at 4°C
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2564486 (BioLegend Cat. No. 673902)
Antigen Details
- Structure
- 1062 amino acids with a predicted molecular weight of 120.5 kD; contains a DAPIN domain, NACT domain, and eight LRR repeats.
- Distribution
-
Cytoplasm
- Function
- NLRP2 is a component of inflammasome that is involved in the activation of caspase-1 and the inhibition of NK&κB signaling.
- Interaction
- NLRP2 interacts wtih IKBKB, IKBKG, CHUK, and MEFV.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Peng H, et al. 2012. PLoS One 7:e30344.
2. Lupfer C, et al. 2013. Front Immunol. 4:285.
3. Minkiewicz J, et al. 2013. Glia. 61:1113.
4. Huang JY, et al. 2013. Hum. Reprod. 28:1127.
5. Fontalba A, et al. 2007. J. Immunol. 179:8519.
6. Bruey JM, et al. 2004. J. Biol. Chem. 50:51897. - Gene ID
- 55655 View all products for this Gene ID
- UniProt
- View information about NLRP2 on UniProt.org
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