Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial mouse XBP-1s recombinant protein (162-267aa)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, ChIP - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per mL. For ChIP application, use 2 ?g of antibody and 10 ?g of chromatin per IP. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The clone 9D11A43 recognizes spliced XBP-1 (XBP-1s/isoform 2), which is 371 amino acids and migrates around 55 kD on the SDS-PAGE.
- Additional Product Notes
Using this antibody at a ratio higher than 1:5 (?g antibody per ug of chromatin) will increase background
- Product Citations
-
- RRID
- AB_2562960 (BioLegend Cat. No. 658802)
Antigen Details
- Distribution
-
Nucleus.
- Function
- Upregulated by ER stress, IL-6, and IL-4. Downregulation correlates with tumor progression in prostate cancer. Downregulated by PAX5 transcription factor.
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- MHC Antigens, Nuclear Markers
- Antigen References
-
1. Liou HC, et al. 1990. Science 247:1581.
2. Ponath PD, et al. 1993. J. Biol. Chem. 268:17074.
3. Takahashi S, et al. 2002. Prostate 50:154. - Gene ID
- 7494 View all products for this Gene ID
- UniProt
- View information about XBP-1s on UniProt.org
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