Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial TRAF3 recombinant protein (1-200 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
KO/KD-WB - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2566432 (BioLegend Cat. No. 680802)
Antigen Details
- Structure
- 568 amino acids with a predicted molecular weight of 64.5 kD. Contains a C-terminal MATH/TRAF domain responsible for the binding to receptor cytoplasmic domains.
- Distribution
-
Cytoplasm.
- Function
- TRAF3 mediates the signal transduction from TNF receptors and Toll-like receptors, leading to the activation of NF-κB, MAP kinases, or IRF3. TRAF3 is involved in the regulation of anti-viral response and B-cell survival.
- Interaction
- TRAF3 forms a homodimer. TRAF3 also forms heterodimers with TRAF2 and TRAF5. TRAF3 also interacts with CD40, TICAM1, TRAFD1, BIRC2, BIRC3, TLR4. TRIP, and TBK1.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Hildebrand JM, et al. 2011. Immunol. Rev. 244:55.
2. Hu H, et al. 2013. Nature 494:371.
3. Jenkinson SR, et al. 2013. Proc. Natl. Acad. Sci. USA 110:21107.
4. Lin WW, et al. 2013. Front Immunol. 4:477.
5. Yi Z, et al. 2014. Cytokine Growth Factor Rev. 25:147.
6. Yi Z, et al. 2014. Nat. Immunol. 15:866. - Gene ID
- 7187 View all products for this Gene ID
- UniProt
- View information about TRAF3 on UniProt.org
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