Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human DDX1 recombinant protein (1-107 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml. For immunocytochemistry, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565509 (BioLegend Cat. No. 675302)
Antigen Details
- Structure
- 740 amino acids with a predicted molecular weight of 82 kD. It contains a DEAD box motif and an ATP-binding helicase domain.
- Distribution
-
Nucleus and cytoplasm.
- Function
- DDX1 is an ATP-dependent RNA helicase and possesses RNA nuclease activity and ATPase activity. DDX1 has been shown to participate in mRNA processing, DNA repair, and transcriptional activation.
- Interaction
- PHF5A, MBNL1, CSTF2, HNRNPK, ATM, and NFκB-p65.
- Biology Area
- Cell Biology, DNA Repair/Replication, Transcription Factors
- Antigen References
-
1. Lin MH, et al. 2014. Retrovirology 11:121.
2. Han C, et al. 2014. Cell Rep. 8:1447.
3. Edgcomb SP, et al. 2012. J. Mol. Biol. 415:61.
4. Taunk NK, et al. 2012. Cancer 118:888.
5. Xu L, et al. 2010. J. Virol. 84:8571.
6. Godbout R, et al. 2007. Future Oncol. 3:575. - Gene ID
- 1653 View all products for this Gene ID
- UniProt
- View information about DDX1 on UniProt.org
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