Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial DDX58 recombinant protein (1-228 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2564246 (BioLegend Cat. No. 662302)
Antigen Details
- Structure
- 925 amino acids with a predicted molecular weight of 107 kD. Contains two CARD domains, one RNA helicase domain and one CTD domain.
- Distribution
-
Cytoplasm
- Function
- DDX58 is a RNA helicase participating in the innate immune responses during viral infection. It acts as a cytoplasmic sensor of viral RNA and activates the production of proinflammatory cytokines and type I interferons.
- Interaction
- DDX58 forms homodimers upon binding to viral double stranded (ds) RNA. Interacts with TMEM173, DHX58, TRIM25, NLRC5, and MAVS.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Goubau D, et al. 2013. Immunity. 38:855.
2. Zhang HX, et al. 2013. Proc. Natl. Acad. Sci. USA. 110:6459.
3. Wang Y, et al. 2013. Innate Immun. 19:193.
4. Oshiumi H, et al. 2012. J. Biochem. 151:5.
5. Kolakofsky D, et al. 2012. RNA. 18:2118.
6. Schlee M, et al. 2010. Mol. Ther. 18:1254. - Gene ID
- 23586 View all products for this Gene ID
- UniProt
- View information about DDX58 on UniProt.org
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