Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human RUNX3 recombinant protein (194-304 aa).
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ChIP - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ChIP Assay. The suggested dilution for ChIP application is 1:50-1:100 by volume. It is recommended that the reagent to be titrated for optimal performance before each experiment.
- Application Notes
The binding of RUNX3 antibody (9F4A17) to its target is sensitive to salt concentration.
- Product Citations
-
- RRID
- AB_2687117 (BioLegend Cat. No. 653603) AB_2687118 (BioLegend Cat. No. 653604)
Antigen Details
- Structure
- 44 kD protein containing a runt domain and a proline/serine/threonine rich domain required for transcriptional activation.
- Distribution
-
Nucleus, the tyrosine phosphorylated form is localized to the cytoplasm.
- Function
- RUNX3 is a transcription factor that forms a heterodimeric complex with CBF beta subunit. The RUNX3 heterodimer binds to numerous enhancers and promoters, activating or suppressing target genes. RUNX3 was reported to function as a tumor suppressor.
- Interaction
- RUNX3 interacts with TLE1, SUV39H1, SRC, FYN, and LCK.
- Cell Type
- Tregs
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Goh YM, et al. 2010. J. Biol. Chem. 285:10122.
2. Vogiatzi P, et al. 2006. Cancer Biol. Ther. 5:371.
3. Inoue K, et al. 2008. Neural Dev. 3:20.
4. Sugai M, et al. 2011. J. Immunol. 186:6515.
5. Ito K, et al. 2005. Cancer Res. 65:7743.
6. Hsu PI, et al. 2009. Ann. Surg. Oncol. 16:1686. - Gene ID
- 864 View all products for this Gene ID
- UniProt
- View information about RUNX3 on UniProt.org
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