Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial human NLRP1 recombinant protein (1-200 a.a.) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2566263 (BioLegend Cat. No. 679802)
Antigen Details
- Structure
- 1473 amino acids with a predicted molecular weight of 165.8 kD. Contains an N-terminal PYD domain, a C-terminal CARD domain, a NACHT domain, and 6 leucine-rich repeats (LRR).
- Distribution
-
Cytoplasm and nucleus.
- Function
- NLRP1 mediates cytochrome c-dependent apoptosis. It is a key component of the NLRP1 inflammasome, which leads to the processing and secretion of IL-1β and IL-18.
- Interaction
- Interacts with caspase-2, caspase-9, APAF1, EIF2AK2, and MEFV.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Antigen References
-
1. Tan CC, et al. 2015. J. Neuroinflammation 12:18.
2. Tan MS, et al. 2014. Cell Death Dis. 5:e1382.
3. Cirelli KM, et al. 2014. PLoS Pathog. 10:e1003927.
4. Maier NK, et al. 2014. J. Immunol. 192:763.
5. Levandowski CB, et al. 2013. Proc. Natl. Acad. Sci. USA 110:2952.
6. de Zoete MR, et al. 2012. Immunity 37:950. - Gene ID
- 22861 View all products for this Gene ID
- UniProt
- View information about NLRP1 on UniProt.org
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