Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length human TICAM-2 recombinant protein expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Daudi cells were selected as a negative control for antibody testing due to the cell line’s low expression level of the mRNA encoding TICAM2 (source: Human Protein Atlas).
- RRID
- AB_2563252 (BioLegend Cat. No. 659402)
Antigen Details
- Structure
- 235 amino acids encode a protein with a predicted MW of 27 kD. Contains a TIR domain responsible for mediating the physical interaction with TLR4 and TICAM-1.
- Distribution
-
Cytoplasm, golgi apparatus, endosome, cell membrane, and endoplasmic reticulum.
- Function
- TICAM-2 acts as a sorting adaptor molecule that transduces TLR4 signaling to TICAM-1 and regulates MYD88-independent pathway in response to LPS stimulation.
- Interaction
- Interacts with TRAF6, MYD88, TLR4, IL1R1, IL1RAP, IRAK2, IRAK3, TICAM1, IRF3, and IRF7.
- Cell Type
- Dendritic cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Signal Transduction
- Antigen References
-
1. Enokizono Y, et al. 2013. Proc. Natl. Acad. Sci. USA. 110:19908.
2. Ohnishi H, et al. 2012. PLoS One. 7:e38423.
3. Wu B, et al. 2011. Dev. Comp. Immunol. 35:764.
4. Seya T, et al. 2005. Int. J. Biochem. Cell Biol. 37:524.
5. Vogel SN, et al. 2003. Mol. Interv. 3:466.
6. Oshiumi H, et al. 2003. J. Biol. Chem. 278:49751. - Gene ID
- 353376 View all products for this Gene ID
- UniProt
- View information about TICAM-2 on UniProt.org
