Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CCL15.
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking. The ND50 is 0.05 - 0.25 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2632767 (BioLegend Cat. No. 692703) AB_2632768 (BioLegend Cat. No. 692704)
Antigen Details
- Distribution
-
CCL15 is produced by smooth muscle cells, basophils, and hepatic carcinoma cells.
- Function
- CCL15 induces migration of monocytes, eosinophils, and lymphocytes. CCL15 is activated by cathepsin G, elastase, and MMPs. TNF?± and IFN?? synergistically induce CCL15 in human airway smooth muscle cells in culture.
- Interaction
- Monocytes, eosinophils, airway smooth muscle cells, hepatic carcinoma cells, human osteogenic sarcoma cells, and osteoclast progenitors.
- Ligand/Receptor
- CCR1, CCR3.
- Cell Type
- Basophils
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Pardigol A, et al. 1998. Proc. Natl. Acad. Sci. USA 95:6308.
2. Richter R, et al. 2005. J. Immunol. 175:1599.
3. Berahovich RD, et al. 2005. J. Immunol. 174:7341.
4. Shimizu Y, et al. 2011. J. Biol. Regul. Homeost. Agents 25:177.
5. Starr AE, et al. 2012. J. Biol. Chem. 287:13382.
6. Weber KL, et al. 2012. PLoS One 7:e40799.
7. Li Y, et al. 2013. Br. J. Cancer 108:99. - Gene ID
- 6359 View all products for this Gene ID
- UniProt
- View information about CCL15 on UniProt.org
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