Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human CCL23 (MPIF-1)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the chemotaxis induced by recombinant Human CCL23 (MPIF-1) (Cat. No. 587004) at 1 ng/mL on mouse Baf3-hCCR1 transfectant chemoattractant cells. ND50 range: 0.01 - 0.05 ?g/mL.? It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2927979 (BioLegend Cat. No. 607553) AB_2927979 (BioLegend Cat. No. 607554)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Monocytes, macrophages, dendritic cells, mucosal epithelial cells, and eosinophils
- Function
- CCL23 attracts monocytes, dendritic cells, and resting lymphocytes. CCL23 induces endothelial cell migration and angiogenesis. CCL23 inhibits colony formation of bone marrow-derived cells. IL-4 and IL-13 induce CCL23 in peripheral blood monocytes, and GM-CSF synergized with IL-4 to induce CCL23. GM-CSF and IL-5 induce CCL23 secretion from eosinophils.
- Interaction
- Monocytes, macrophages, epithelial cells, and dendritic cells
- Ligand/Receptor
- CCR1
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Patel VP, et al. 1997. J Exp Med. 185:1163-72.
- Macphee CH, et al. 1998. J Immunol. 161:6273-9.
- Hwang J, et al. 2005. Cytokine. 30:254-63.
- Berahovich RD, et al. 2005. J Immunol. 174:7341-51.
- Novak H, et al. 2007. J Immunol. 178:4335-41.
- Rioja I, et al. 2008. Arthritis Rheum. 58:2257-67.
- Poposki JA, et al. 2011. J Allergy Clin Immunol. 128:73-81.
- Starr AE, et al. 2012. J Biol Chem. 287:5848-60.
- Gene ID
- 6368 View all products for this Gene ID
- UniProt
- View information about CCL23 on UniProt.org
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