Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant full length of human NTRK2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Optimal concentration of usage is 0.1 - 1 ?g/mL for WB. The optimal concentration should be determined by titration for each individual assay of interest
- RRID
- AB_2686965 (BioLegend Cat. No. 695102)
Antigen Details
- Structure
- Human NTRK2 has 7 isoforms, and predicted Mw ranges from 35 to 93kDa. It has 11 potential N-glycosylation sites.
- Distribution
-
NTRK2 is found primarily in the nervous system. It also can be found in the pancreas, skeletal muscles, and the kidney. A truncated form of TrkB (missing the tyrosine kinase domain) is found in heart, ovary, and the spleen.
- Function
- NTRK2, when binded to BDNF, NT-3, and NT-4, is able to exert neuron cells' biological functions such as proliferation, survival, axon, and dendrite growth.
- Interaction
- Interacts with SHC1, PLCG1 and/or PLCG2, SH2B1 and SH2B2, NGFR, SH2D1A, SQSTM1 and KIDINS220, FRS2.
- Ligand/Receptor
- BDNF, NT-3 and NT-4.
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Molecular Family
- Soluble Receptors, Protein Kinases/Phosphatase
- Antigen References
-
1. Snider WD. 1994. Cell 77:627.
2. Grace PM, et al. 2014. Nat. Rev. Immunol. 14:217.
3. Neveu I and Arenas E. 1996. J. Cell Biol. 133:631.
4. Green CR, et al. 2013. J. Depress Anxiety S4:006.
5. Gupta VK, et al. 2013. Int. J. Mol. Sci. 14:10122.
6. Pla P, et al. 2014. Front Behav. Neurosci. 8:135.
7. Liu X, et al. 2014. J. Biol. Chem. 289:27571. - Gene ID
- 4915 View all products for this Gene ID
- UniProt
- View information about NTRK2 on UniProt.org
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