Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant human CCL7.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2616886 (BioLegend Cat. No. 686702)
Antigen Details
- Structure
- Chemokine.
- Distribution
- Fibroblasts, mast cells, astrocytes, endothelial cells, monocytes, and macrophages.
- Function
- CCL7 chemoattracts monocytes, T cells, NK cells, eosinophils, and basophils. CCL7 protein is secreted by mononuclear leukocytes after stimulation with IL-1β, IFN-α, IFN-β, measles virus, poly I-C, or Con A. In fibroblasts, CCL7 mRNA and protein are synergistically induced after treatment with IL-1β and IFN-γ. CCL7 is stimulated in murine fibroblasts and astrocytes by TGF-β and TNF-α respectively. Anti-inflammatory cytokines (IL-4, IL-10, or IL-13) inhibit the expression of CCL7 in monocytes.
- Interaction
- Monocytes, T cells, NK cells, dendritic cells, mast cells, eosinophils, and basophils.
- Ligand/Receptor
- CCR1 (CD191), CCR2 (CD192), CCR3 (CD193), and CCR5 (CD195).
- Cell Type
- Fibroblasts, Mast cells, Astrocytes, Endothelial cells, Monocytes, Macrophages
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Van Damme J, et al. 1992. J. Exp. Med. 176:59.
2. Menten P, et al. 1999. Eur. J. Immunol. 29:678.
3. McQuibban GA, et al. 2000. Science 289:1202.
4. Menten P, et al. 2001. Eur. Cytokine Netw. 12:554.
5. Dean RA, et al. 2008. Blood 112:3455.
6. Renner NA, et al. 2011. J. Neurovirol. 17:146.
7. Hwang TL, et al. 2012. World J. Gastroenterol. 18:1249.
8. Feuser K, et al. 2012. Cytokine 58:178. - Gene ID
- 6354 View all products for this Gene ID
- UniProt
- View information about CCL7 on UniProt.org
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