Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human CCL24
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g/ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2572025 (BioLegend Cat. No. 683602)
Antigen Details
- Structure
- 93 amino acids with a predicted molecular weight of 10.4 KD.
- Distribution
- CCL24 is expressed by epithelial cells, airway smooth muscle cells, and vascular endothelial cells. In addition, eotaxins are produced by cells isolated by bronchial alveolar lavage, including macrophages, monocytes, basophils, eosinophils, and lymphocytes.
- Function
- CCL24 attracts CCR3+ cells such as eosinophils, mast cells, basophils, and Th2 cells that play a role in allergic disorders. IL-4 and IL-13 induce CCL11 and CCL24 in esophagus and colonic epithelial cell, and IL-13 induces the production of CCL24 in dendritic cells and alveolar macrophages. In addition, CCL24 is induced by IL-33 in lung and by IL-4 and LPS in monocytes and macrophages. The expression of CCL24 by alveolar epithelial cells requires histamine and its receptor H2R.
- Interaction
- Eosinophils, mast cells, Th2 lymphocytes, basophils, human dendritic cells, synovial tissue macrophages, lung epithelial cells, and airway smooth muscle cells.
- Ligand/Receptor
- CCR3
- Cell Type
- Epithelial cells, Endothelial cells, Macrophages, Monocytes, Basophils, Eosinophils, Lymphocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Patel VP, et al. 1997. J. Exp. Med. 185:1163.
2. Beaulieu S, et al. 2002. J. Immunol. 169:2925.
3. Watanabe K, et al. 2002. J. Immunol. 168:1911.
4. Ablin JN, et al. 2010. Clin. Exp. Immunol. 161:276.
5. Manousou P, et al. 2010. Clin. Exp. Immunol. 162:337.
6. Stolarski B, et al. 2010. J. Immunol. 185:3472.
7. Crapster-Pregont M, et al. 2012. J. Allergy Clin. Immunol. 129:1621.
8. Swartzendruber JA, et al. 2012. J. Immunol. 188:536. - Gene ID
- 6369 View all products for this Gene ID
- UniProt
- View information about CCL24 on UniProt.org
我要詢價
*聯(lián)系方式：
(可以是QQ、MSN、電子郵箱、電話等，您的聯(lián)系方式不會被公開)
*內(nèi)容：
