Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Oncostatin M
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by the inhibition of proliferation induced by recombinant human Oncostatin M (Cat. No. 555202) at 2.2 ng/mL on TF-1 cells. ND50 range: 0.5 -2 μg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2910474 (BioLegend Cat. No. 601653) AB_2910474 (BioLegend Cat. No. 601654)
Antigen Details
- Structure
- Cytokine
- Distribution
-
Activated monocytes, macrophages, T cells including skin-infiltrating T cells, and dendritic cells
- Function
- Proinflammatory mediator and keratinocyte activator, induces acute phase protein synthesis, hematopoiesis, and bone remodeling
- Interaction
- Keratinocytes, fibroblasts, endothelia, hepatic cells, lung, hematopoietic cells, epithelial cells, and smooth muscle cells
- Ligand/Receptor
- Receptor complex: type I and type II complexes are formed by oncostatin M receptor (OSMR), LIFR, and p130 (IL-6 signal transducer).
- Cell Type
- Embryonic Stem Cells, Hematopoietic stem and progenitors
- Biology Area
- Cell Proliferation and Viability, Immunology, Stem Cells
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
- Zarling JM, et al. 1986. Proc Natl Acad Sci USA. 83:9739-43.
- Rose TM and Bruce AG. 1991 Proc Natl Acad Sci USA. 88: 8641-5.
- Mosley B, et al. 1996. J Biol Chem. 271:32635-43.
- Dillon SR, et al. 2004. Nat Immunol. 5:752-60.
- Boniface K, et al. 2007. J Immunol. 178:4615-22.
- Beigel F, et al. 2014. PLoS One. 9:e93498.
- Schnittker D, et al. 2013. Mediators Inflamm. 2013:317503.
- Gene ID
- 5008 View all products for this Gene ID
- UniProt
- View information about Oncostatin M on UniProt.org
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