Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CXCL7
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant mouse CXCL7 (NAP-2) (Cat. No. 586704) (3 ng/mL) on mouse Baf3-mCXCR2 transfectant chemoattractant cells. ND50 range: 0.3 - 2 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2910505 (BioLegend Cat. No. 945703) AB_2910505 (BioLegend Cat. No. 945704)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Platelets, neutrophils, lymphocytes, macrophages, endothelial cells
- Function
- CXCL7 stimulates chemotaxis and degranulation in neutrophils, induces transendothelial migration and neutrophil adhesion to activated endothelial cells, and has angiogenic activity. LPS induces the precursor in PBMCs
- Interaction
- Neutrophils, keratinocytes
- Ligand/Receptor
- CXCR2
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Iida N, et al. 1996. FASEB J. 10:1336-45.
- Schenk BI, et al. 2002. J Immunol. 169:2602-10.
- El-Gedaily A, et al. 2004. J Leukoc Biol. 75:495-503.
- Schiemann F, et al. 2006. Blood. 107:2234-42.
- Tang Z, et al. 2008. Am J Surg. 196:690-6.
- Yee J, et al. 2009. J Clin Oncol. 27:2787-92.
- Yu M, et al. 2010. J Oncol. 2010:939407.
- Lee G, et al. 2011. Am J Transl Res. 3:226-33.
- Nguyen LT and Vogel HJ. 2012. Front Immunol. 3:384.
- Gene ID
- 57349 View all products for this Gene ID
- UniProt
- View information about CXCL7 on UniProt.org
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