Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-12.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2632765 (BioLegend Cat. No. 692502)
Antigen Details
- Structure
- 328 amino acids with a predicted molecular weight of 40 kD.
- Distribution
- Secreted.
- Function
- p40 homodimer functions as a proinflammatory protein that enhances leukocyte accumulation in the skin, blunt Th1 immunity to Plasmodium berghei, and provides protective immunity toward mycobacterial infection. In addition, p40 homodimer induces macrophage chemotaxis independent of IL-12. Also, IL-12 p40 homodimer (p402) induces the expression of inducible nitric oxide synthase (iNOS) in microglia.
- Interaction
- Heterodimer with IL12A and IL23A.
- Ligand/Receptor
- IL-12Rβ1.
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Schoenhaut DS, et al. 1992. J. Immunol. 148:3433.
2. Manetti R, et al. 1994. J. Exp. Med. 179:1273.
3. Ireland D, et al. 2005. Viral Immunol. 18:397.
4. Moreno SE, et al. 2006. J. Immunol. 177:3218.
5. Lyakh L, et al. 2008. Immunol. Rev. 226:112.
6. Theiner G, et al. 2008. Mol. Immunol. 45:244.
7. Zhu S, et al. 2010. J. Immunol. 184:2348. - Gene ID
- 3593 View all products for this Gene ID
- UniProt
- View information about IL-12 p40 on UniProt.org
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