Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human FOXP3 delta2 (exon 2 deleted) peptide conjugated to KLH.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is against human FOXP3 delta 2, molecular weight of 43 kD, and weakly reacts with full length human FOXP3, molecular weight 47 kD.
- RRID
- AB_2650734 (BioLegend Cat. No. 694802)
Antigen Details
- Structure
- Forkhead/winged-helix transcription factor family, exon 2 deleted, approximately 43 kD, contains zinc finger and forkhead domains
- Distribution
-
Nuclear; expressed in T regulatory cells.
- Function
- Transcription factor proposed to be a master regulatory gene in T regulatory cell development and a critical factor for immune homeostasis.
- Interaction
- IKZF3, STUB1, HSPA8 and HSPA1A/B, PPP1CA, PPP1CB, PPP1CG, KAT5, HDAC7, HDAC9, USP7, RUNX1, RORC, RUNX2, RUNX3 and IKZF4.
- Cell Type
- Tregs
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Chromatin Remodeling/Epigenetics, Immunology, Innate Immunity, Signal Transduction, Transcription Factors, Ubiquitin/Protein Degradation
- Antigen References
-
1. Kristensen B, et al. 2015. Clin. Exp. Immunol. 180:58.
2. Roncador G, et al. 2005. Eur. J. Immunol. 35:1681.
3. Mayack S, et al. 2006. J. Immunol. 176:2059.
4. Yang ZZ, et al. 2006. Blood 107:3639.
5. Gavin MA, et al. 2006. Proc. Natl. Acad. Sci. USA 103:6659.
6. Groh V, et al. 2006. Nature Immunology 7:755.
7. Lewkowicz P, et al. 2006. J. Immunol. 177:7155.
8. Luke PP, et al. 2006. Am. J. Transplant. 6(9):2023.
9. Bamias G, et al. 2007. J. Immunol. 178:1809.
10. Valencia X, et al. 2007. J. Immunol. 178:2579.
11. Davidson TS, et al. 2007. J. Immunol. 178:4022. - Gene ID
- 50943 View all products for this Gene ID
- UniProt
- View information about FOXP3 on UniProt.org
